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KMID : 0363420200340040011
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Journal of Korean Oriental Pediatrics
2020 Volume.34 No. 4 p.11 ~ p.21
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The Efficacy of Ephedra sinica, Panax ginseng, and Alisma orientale Extract on Insulin resistance induced by Non-alcoholic fatty liver disease (NAFLD)
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Kim Ki-Bong
Ahn Sang-Hyun
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Abstract
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Objectives: This study aimed to investigate the efficacy of Ephedra sinica (E. sinica), Panax ginseng (P. ginseng), and Alisma orientale (A. orientale) Extract (MIT) on insulin resistance induced by Non-alcoholic fatty liver disease (NAFLD).
Methods: C57BL /6 male mice (8-week-old, 20 g) were divided into four groups: control group (Ctrl), high-fat diet group (HFDF), high fat diet with metformin administration group (METT), and high fat diet with MIT administration group (MITT). Each 10 mice were allocated to each group (a total of 40 mice). All mice were allowed to eat fat-rich diet freely throughout the experiment. To examine the effect of MIT, we observed Cannabinoid receptor type 1 (CB1), Cannabinoid receptor type 2 (CB2), G protein-coupled receptor 55 (GPR55), and Transforming growth factor-β (TGF-β).
Results: In the MITT group, positive reactions of the CB1, CB2, and GPR55 were significantly was significantly suppressed compared to the HFDF group. The positive reactions of the CD36 and TGF-β in the liver tissue were significantly suppressed in MITT.
Conclusions: MIT has the effect of improving NAFLD induced insulin resistance through the regulation of the lipid metabolism.
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KEYWORD
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Ephedra sinica, Panax ginseng, Alisma orientale, Non-alcoholic fatty liver disease, Insulin resistance
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